Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to
define adequately. Despite its importance as a public health problem, efforts to develop and …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …

Objective: To evaluate the performance of total maximum sequential organ failure
assessment (SOFA) score and a derived measure, delta SOFA (total maximum SOFA score …

During the past few decades, intensive collaborative research in the fields of chronic and
acute inflammatory disorders has resulted in a better understanding of the pathophysiology …

Sepsis, a life-threatening disorder that arises through the body's response to infection, is the
leading cause of death and disability for patients in an intensive care unit. Advances in the …

Anaphylaxis is an acute, severe, life-threatening multisystem allergic reaction resulting from
the sudden systemic release of biochemical mediators and chemotactic substances …

The platelet-activating factor (PAF) signaling cascade evolved as a component of the
repertoire of innate host defenses, but is also an effector pathway in inflammatory and …

Inflammatory lipid mediators are produced by the metabolism of membrane phospholipids
following a number of different stimuli. These mediators lead to a variety of cellular and …

Background: Leukocytes, also called white blood cells, can be categorized into three main
groups, granulocytes, monocytes, and lymphocytes, which can be further classified into …

Traditionally, disease is thought to result from an insufficient response of the host to
infection, leading to increased replication of microorganisms and consequently disease …