Human plasma protein N-glycosylation

F Clerc, KR Reiding, BC Jansen, GSM Kammeijer… - Glycoconjugate …, 2016 - Springer
Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

[HTML][HTML] An overview of molecular basis of iron metabolism regulation and the associated pathologies

B Silva, P Faustino - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

A Salvati, AS Pitek, MP Monopoli, K Prapainop… - Nature …, 2013 - nature.com
Nanoparticles have been proposed as carriers for drugs, genes and therapies to treat
various diseases,. Many strategies have been developed to target nanomaterials to specific …

Designing the nanoparticle–biomolecule interface for “targeting and therapeutic delivery”

E Mahon, A Salvati, FB Bombelli, I Lynch… - Journal of Controlled …, 2012 - Elsevier
The endogenous transport mechanisms which occur in living organisms have evolved to
allow selective transport and processing operate on a scale of tens of nanometers. This …

Intracellular iron transport and storage: from molecular mechanisms to health implications

EL Mackenzie, K Iwasaki, Y Tsuji - Antioxidants & redox signaling, 2008 - liebertpub.com
Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

Mammalian iron transport

GJ Anderson, CD Vulpe - Cellular and Molecular Life Sciences, 2009 - Springer
Iron is essential for basic cellular processes but is toxic when present in excess.
Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to …

Oxidative stress: free radical production in neural degeneration

ME Götz, G Künig, P Riederer, MBH Youdim - Pharmacology & therapeutics, 1994 - Elsevier
It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

Biomimetic strategies for targeted nanoparticle delivery

D Dehaini, RH Fang, L Zhang - Bioengineering & translational …, 2016 - Wiley Online Library
Nanoparticle‐based drug delivery and imaging platforms have become increasingly popular
over the past several decades. Among different design parameters that can affect their …

Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia

BJ Ferguson, BS Skikne, KM Simpson… - The Journal of …, 1992 - translationalres.com
Recent studies have shown that the serum transferrin receptor is a sensitive, quantitative
measure of tissue iron deficiency. This study was undertaken to determine the serum …

Structures and functionalities of milk proteins

DWS Wong, WM Camirand, AE Pavlath… - Critical Reviews in …, 1996 - Taylor & Francis
During the last decade, marked progress has been made in the study of the fine details of
the structures of milk proteins such as caseins, β‐lactoglobulin, α‐lactalbumin, and …