The amyloid cascade hypothesis: an updated critical review
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …
disease have created excitement and have been heralded as corroboration of the amyloid …
[HTML][HTML] A current view on Tau protein phosphorylation in Alzheimer's disease
S Wegmann, J Biernat, E Mandelkow - Current opinion in neurobiology, 2021 - Elsevier
The functions of the neuronal microtubule-associated protein Tau in the central nervous
system are regulated by manifold posttranslational modifications at more than 50 sites. Tau …
system are regulated by manifold posttranslational modifications at more than 50 sites. Tau …
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
[HTML][HTML] Tau PTM profiles identify patient heterogeneity and stages of Alzheimer's disease
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
B Caballero, M Bourdenx, E Luengo, A Diaz… - Nature …, 2021 - nature.com
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
The complexity of tau in Alzheimer's disease
NN Naseri, H Wang, J Guo, M Sharma, W Luo - Neuroscience letters, 2019 - Elsevier
Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …
Tau and tauopathies
T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
The road to restoring neural circuits for the treatment of Alzheimer's disease
Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …
Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease
X Zhang, L Tang, J Yang, L Meng, J Chen… - Nature …, 2023 - nature.com
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein that
is predominantly expressed by microglia in the brain. The proteolytic shedding of TREM2 …
is predominantly expressed by microglia in the brain. The proteolytic shedding of TREM2 …