Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Chronic kidney disease (CKD) has emerged as a major cause of morbidity and mortality
worldwide. Interstitial fibrosis, glomerulosclerosis and inflammation play the central role in …

Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that
typically occurs in renal surgeries. However, renal I/R still currently lacks effective …

Unilateral ureteral obstruction (UUO) is an experimental rodent model that mimics renal
fibrosis associated with obstructive nephropathy in an accelerated manner. After UUO, the …

Rationale: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been
shown to block cardiac fibrosis in preclinical models of heart failure (HF). However, since the …

Chronic kidney disease (CKD), characterized as renal dysfunction, is recognized as a major
public health problem with high morbidity and mortality worldwide. Unfortunately, there are …

The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …

The endogenous repair process can result in recovery after acute kidney injury (AKI) with
adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and …

Reactive oxygen species derived from NADPH oxidase contribute to a wide variety of renal
diseases. Nox4, the major NADPH isoform in kidney, produces mainly H 2 O 2 that regulates …