Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …

Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is
expressed in almost all cell types in humans, unlike the other proteins of the PTBP family …

Direct reprogramming of glia into neurons is a potentially promising approach for the
replacement of neurons lost to injury or neurodegenerative disorders. Knockdown of the …

Functions of many long noncoding RNAs (lncRNAs) depend on their ability to interact with
multiple copies of specific RNA-binding proteins (RBPs). Here, we devised a workflow …

A major function of TAR DNA-binding protein-43 (TDP-43) is to repress the inclusion of
cryptic exons during RNA splicing. One of these cryptic exons is in UNC13A, a genetic risk …

Long mammalian introns make it challenging for the RNA processing machinery to identify
exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection …

The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA
binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA …

While dysregulation of RNA splicing has been recognized as an emerging target for cancer
therapy, the functional significance of RNA splicing and individual splicing factors in brain …

Sporadic inclusion body myositis (IBM) is the most common acquired muscle disease in
adults over age 50, yet it remains unclear whether the disease is primarily driven by T cell …

Nuclear depletion of TDP-43, an essential RNA binding protein, may underlie
neurodegeneration in amyotrophic lateral sclerosis (ALS). As several functions have been …