Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …

Introduction: Drug delivery systems (DDSs) are important for effective, safe, and convenient
administration of drugs. pH-and ion-responsive polymers have been widely employed in …

Poly (amino ester) s (PAEs) refer to a class of synthetic polymers characterized by repeating
units in the backbone having tertiary amines and ester bonds, and bringing together the …

The development of safe and efficient gene delivery vectors is an essential prerequisite for
successful gene therapy. As viral vectors suffer from inherent disadvantages, cationic …

Despite extensive investigations in the field of cancer diagnosis and therapy in recent
decades, cancer is still the major cause of morbidity and mortality all over the world …

High cationic charge densities in polymeric vectors result in tight DNA condensation, leading
to small highly positively charged polyplexes which show generally high cellular uptake in …

In this study, the gene delivery properties of new hyperbranched poly (amido amine) s
(PAAs) with disulfide linkages in the main chain were investigated in comparison with their …

Background: An essential prerequisite for successful gene therapy is the development of
safe and efficient gene delivery carriers. For this purpose, cationic polymers have been …

Nanopharmaceutics composed of a carrier and a protein have the potential to improve the
activity of therapeutical proteins. Therapy for lysosomal diseases is limited by the lack of …

In order to improve the transfection efficiency (TE) and biocompatibility, we synthesized a
series of hyperbranched cationic polymers by ring-opening polymerization between …