The dihydroorotate dehydrogenases: past and present
The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …
Medicinal chemistry approaches for the discovery of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors as antimalarial agents
Malaria is a severe human disease and a global health problem because of drug-resistant
strains. Drugs reported to prevent the growth of Plasmodium parasites target various phases …
strains. Drugs reported to prevent the growth of Plasmodium parasites target various phases …
Evaluation of 7-arylaminopyrazolo [1, 5-a] pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
LFSP Azeredo, JP Coutinho, VAP Jabor… - European Journal of …, 2017 - Elsevier
Malaria remains one of the most serious global infectious diseases. An important target for
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH …
FF Silveira, JO de Souza, LVB Hoelz… - European Journal of …, 2021 - Elsevier
In this work, we designed and synthesized 35 new triazolopyrimidine, pyrazolopyrimidine
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …
Trypanosoma cruzi nitroreductase: Structural features and interaction with biological membranes
Due to its severe burden and geographic distribution, Chagas disease (CD) has a significant
social and economic impact on low-income countries. Benznidazole and nifurtimox are …
social and economic impact on low-income countries. Benznidazole and nifurtimox are …
[HTML][HTML] Solvent concentration at 50% protein unfolding may reform enzyme stability ranking and process window identification
FA Sorgenfrei, JJ Sloan, F Weissensteiner… - Nature …, 2024 - nature.com
As water miscible organic co-solvents are often required for enzyme reactions to improve eg,
the solubility of the substrate in the aqueous medium, an enzyme is required which displays …
the solubility of the substrate in the aqueous medium, an enzyme is required which displays …
[HTML][HTML] New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom
FG Amorim, DL Menaldo, SEI Carone, TA Silva… - Toxins, 2018 - mdpi.com
Snake venom serine proteases (SVSPs) are enzymes that are capable of interfering in
various parts of the blood coagulation cascade, which makes them interesting candidates for …
various parts of the blood coagulation cascade, which makes them interesting candidates for …
Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase
The flavoenzyme dihydroorotate dehydrogenase (DHODH) catalyzes the fourth reaction of
the de novo pyrimidine biosynthetic pathway, which exerts vital functions in the cells …
the de novo pyrimidine biosynthetic pathway, which exerts vital functions in the cells …
Glutathione reductase: A cytoplasmic antioxidant enzyme and a potential target for phenothiazinium dyes in Neospora caninum
Neospora caninum causes heavy losses related to abortions in bovine cattle. This parasite
developed a complex defense redox system, composed of enzymes as glutathione …
developed a complex defense redox system, composed of enzymes as glutathione …
Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities
LM Feitosa, RRF Franca, GF Maria de Lourdes… - European Journal of …, 2024 - Elsevier
Abstract The World Health Organization (WHO) estimated that there were 247 million
malaria cases in 2021 worldwide, representing an increase in 2 million cases compared to …
malaria cases in 2021 worldwide, representing an increase in 2 million cases compared to …