Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Cells harness multiple pathways to maintain lysosome integrity, a central homeostatic
process. Damaged lysosomes can be repaired or targeted for degradation by lysophagy, a …

Non-canonical autophagy is a key cellular pathway in immunity, cancer, and
neurodegeneration, characterized by conjugation of ATG8 to endolysosomal single …

Fusobacterium nucleatum in colorectal cancer (CRC) tissue is implicated at multiple stages
of the disease, while the mechanisms underlying bacterial translocation and colonization …

The delivery of pathogens to lysosomes for degradation provides an important defense
against infection. Degradation is enhanced when LC3 is conjugated to endosomes and …

Proton leakage from organelles is a common signal for noncanonical light chain 3B (LC3B)
lipidation and inflammasome activation, processes induced upon stimulator of interferon …

Abstract The caspase-4/11-GSDMD pyroptosis axis recognizes cytosolic lipopolysaccharide
for antibacterial defenses. Shigella flexneri employs an OspC3 effector to block pyroptosis …

Endoplasmic reticulum (ER)-phagy is crucial to regulate the function and homeostasis of the
ER via lysosomal degradation, but how it is initiated is unclear. Here we discover that Z-AAT …

Autophagy refers to a set of degradative mechanisms whereby cytoplasmic contents are
targeted to the lysosome. This is best described for macroautophagy, where a double …