The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the
cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible …

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling
processes that are critical for differentiation and proliferation. Not surprisingly, loss of …

Pathology and Genetics of Head and Neck Tumoursis the latest volume in the new WHO
series, on histological and genetic typing of human tumours. This authoritative, concise …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

Nasopharyngeal carcinoma (NPC) is a prevalent tumour in southern China and southeast
Asia, particularly in the Cantonese population, where its incidence has remained high for …

Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable racial and geographic
distribution. The development of this EBV-associated cancer likely involves cumulative …

Nasopharyngeal carcinoma is a rare disease in children with distinct epidemiological,
histopathological, and clinical characteristics. Incidence varies widely around the world but …

Nasopharyngeal carcinoma (NPC) is a common cancer in South China but is rare in other
parts of the world. To better understand the molecular basis of this cancer, we performed …

Genome instability has been implicated in the generation of multiple somatic mutations that
underlie cancer. Germline mutation in the retinoblastoma (RB) gene leads to tumor …

The E2F transcription factors mediate the activation or repression of key cell cycle regulatory
genes under the control of the retinoblastoma protein (pRB) tumor suppressor and its …