All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …

Many gene sequences in eukaryotic genomes encode entire proteins or large segments of
proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly …

Protein folding and binding are analogous processes, in which the protein 'searches' for
favourable intramolecular or intermolecular interactions on a funnelled energy landscape …

Intrinsically disordered proteins (IDPs) frequently function in protein interaction networks that
regulate crucial cellular signaling pathways. Many IDPs undergo transitions from disordered …

In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding
transcription factors that recognize promoter and enhancer elements near the transcriptional …

The sterol regulatory element binding protein (SREBP) family of transcription activators are
critical regulators of cholesterol and fatty acid homeostasis,. We previously demonstrated …

Although allostery draws increasing attention, not much is known about allosteric
mechanisms. Here we argue that in all proteins, allosteric signals transmit through multiple …

Multidrug resistance (MDR) is a serious complication during treatment of opportunistic
fungal infections that frequently afflict immunocompromised individuals, such as transplant …

The 19F isotope is 100% naturally abundant and is the second most sensitive and stable
NMR-active nucleus. Unlike the ubiquitous hydrogen atom, fluorine is nearly absent in …