The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

For over two decades, the minority stress model has guided research on the health of
sexually-diverse individuals (those who are not exclusively heterosexual) and gender …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

We review research showing that rumination has multiple negative consequences:(a)
exacerbating psychopathology by magnifying and prolonging negative mood states …

Objective: Interest in candidate gene and candidate gene-by-environment interaction
hypotheses regarding major depressive disorder remains strong despite controversy …

A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Women are about twice as likely as are men to develop depression during their lifetime. This
Series paper summarises evidence regarding the epidemiology on gender differences in …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …