Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals …

M Sobanska, S Scholz, AM Nyman… - Environmental …, 2018 - Wiley Online Library
Abstract In 2013 the Organisation for Economic Co‐operation and Development (OECD) test
guideline (236) for fish embryo acute toxicity (FET) was adopted. It determines the acute …

Hypo-or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior …

A Ogungbemi, D Leuthold, S Scholz… - Environmental Sciences …, 2019 - Springer
Tests with zebrafish embryos have gained wide acceptance as an alternative test model for
drug development and toxicity testing. In particular, the behavioral response of the zebrafish …

Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS

S Gaballah, A Swank, JR Sobus… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial
chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is …

Yolk sac of zebrafish embryos as backpack for chemicals?

K Halbach, N Ulrich, KU Goss, B Seiwert… - Environmental …, 2020 - ACS Publications
The zebrafish embryo (Danio rerio) has developed into one of the most important
nonsentient animal models for the hazard assessments of chemicals, but the processes …

Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®

AO Ogungbemi, E Teixido, R Massei, S Scholz… - Neurotoxicology and …, 2020 - Elsevier
Neuroactive chemicals are frequently detected in the environment. At sufficiently high
concentrations or within mixtures, they could provoke neurotoxic effects and neurological …

Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish (Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios

F Zindler, S Tisler, AK Loerracher… - Environmental …, 2020 - ACS Publications
Fluoxetine has been recognized as one of the most toxic pharmaceuticals in the aquatic
environment. Since there is growing evidence that the toxic potential of fluoxetine in surface …

Dose-dependent effects of a glyphosate commercial formulation–Roundup® UltraMax-on the early zebrafish embryogenesis

GAB Lanzarin, LM Felix, D Santos, CAS Venancio… - Chemosphere, 2019 - Elsevier
The use of herbicides with glyphosate as an active ingredient, the so-called glyphosate-
based herbicides (GBH), has increased dramatically in recent years currently being the most …

Toxicokinetics of Polar Chemicals in Zebrafish Embryo (Danio rerio): Influence of Physicochemical Properties and of Biological Processes

S Brox, B Seiwert, E Küster… - Environmental science & …, 2016 - ACS Publications
The time-resolved uptake of 17 nonionic and ionic polar compounds (log D≤ 2) with a
diversity of functional groups into zebrafish embryos (ZFE) was studied over 96 h of …

Influence of pH on the uptake and toxicity of β-blockers in embryos of zebrafish, Danio rerio

L Bittner, E Teixido, B Seiwert, BI Escher, N Klüver - Aquatic Toxicology, 2018 - Elsevier
Abstract ß-Blockers are weak bases with acidity constants related to their secondary amine
group. At environmental pH they are protonated with the tendency to shift to their neutral …

Shedding light on the impacts of gestational exposure to polystyrene nanoplastics on the reproductive performance of Poecilia reticulata female and on the …

G Malafaia, RH Nóbrega, TM da Luz… - Journal of Hazardous …, 2022 - Elsevier
Although the toxicity of nanoplastics (NPs) has already been reported in experimental
aquatic models, their possible effects on the reproductive performance of viviparous …