Viral encounters with 2′, 5′-oligoadenylate synthetase and RNase L during the interferon antiviral response
RH Silverman - Journal of virology, 2007 - Am Soc Microbiol
RNA cleavage is a fundamental host response for controlling viral infections in both plants
and animals (26). In higher vertebrates, this process is often regulated by interferons (IFNs) …
and animals (26). In higher vertebrates, this process is often regulated by interferons (IFNs) …
DNA-encoded library screening to inform design of a ribonuclease targeting chimera (RiboTAC)
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by
facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the …
facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the …
Targeted degradation of structured RNAs via ribonuclease-targeting chimeras (RiboTacs)
S Haj-Yahia, A Nandi, RI Benhamou - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction RNA structural motifs can serve as recognition sites for proteins or regulatory
elements. Notably, these specific RNA shapes are directly related to many diseases …
elements. Notably, these specific RNA shapes are directly related to many diseases …
[HTML][HTML] Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology
Many viruses induce hepatitis in humans, highlighting the need to understand the
underlying mechanisms of virus-induced liver pathology. The murine coronavirus, mouse …
underlying mechanisms of virus-induced liver pathology. The murine coronavirus, mouse …
[HTML][HTML] RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R
(PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR …
(PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR …
Patterns of evolution and host gene mimicry in influenza and other RNA viruses
BD Greenbaum, AJ Levine, G Bhanot… - PLoS …, 2008 - journals.plos.org
It is well known that the dinucleotide CpG is under-represented in the genomic DNA of many
vertebrates. This is commonly thought to be due to the methylation of cytosine residues in …
vertebrates. This is commonly thought to be due to the methylation of cytosine residues in …
Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response
One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues
involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L …
involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L …
Virus-Host Coevolution: Common Patterns of Nucleotide Motif Usage in Flaviviridae and Their Hosts
Virus-host biological interaction is a continuous coevolutionary process involving both host
immune system and viral escape mechanisms. Flaviviridae family is composed of fast …
immune system and viral escape mechanisms. Flaviviridae family is composed of fast …
Functionally conserved architecture of hepatitis C virus RNA genomes
Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of
liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA …
liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA …
Causes and implications of codon usage bias in RNA viruses
IS Belalov, AN Lukashev - PloS one, 2013 - journals.plos.org
Choice of synonymous codons depends on nucleotide/dinucleotide composition of the
genome (termed mutational pressure) and relative abundance of tRNAs in a cell …
genome (termed mutational pressure) and relative abundance of tRNAs in a cell …