Succinate dehydrogenase complex subunit C (SDHC) is a subunit of mitochondrial complex
II (MCII), which is also known as succinate dehydrogenase (SDH) or succinate: ubiquinone …

Metastatic pheochromocytoma and paraganglioma (PPGL) have poor prognosis and limited
therapeutic options. The recent advent of immunotherapies showing remarkable clinical …

Head and neck paragangliomas (HNPGLs) are tumors of parasympathetic origin that occur
at variable locations and are often secondary to germline mutations in succinate …

The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …

Head and neck paragangliomas (HNPGLs) are rare neoplasms that represent difficult
treatment paradigms in neurotology. Germline mutations in genes encoding succinate …

The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …

The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of
function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL) …

Simple Summary The standard interpretation methods of germline variants in cancer are
limited due to overlapping features in constitutional and sporadically derived forms of …

Tumors of the endocrine glands are common. Knowledge of their molecular pathology has
greatly advanced in the recent past. This review covers the main molecular alterations of …

Background Succinate dehydrogenase subunit B (SDHB) immunohistochemistry was
considered a valuable tool to identify patients with inherited paraganglioma …