Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …

OBJECTIVE—Based on rodent studies, we examined the hypothesis that increased adipose
tissue (AT) mass in obesity without an adequate support of vascularization might lead to …

In the past years, the management of diabetic retinopathy (DR) relied primarily on a good
systemic control of diabetes mellitus, and as soon as the severity of the vascular lesions …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …

Peroxisome proliferator-activated receptors (PPARs) belong to the family of ligand-activated
nuclear receptors. The PPAR family consists of three subtypes encoded by three separate …

Simple Summary The roles of peroxisome proliferator-activated receptors (PPARs) in
carcinogenesis are increasingly appreciated. With the growing interest in tumor stromal …

Two independent clinical studies have reported that fenofibrate, a peroxisome proliferator-
activated receptor α (PPARα) agonist, has robust therapeutic effects on microvascular …

Pulmonary arterial hypertension (PAH) is a progressive disease of distal pulmonary arteries
in which patients suffer from elevated pulmonary arterial pressure, extensive vascular …

Background. Neoangiogenesis after cerebral ischemia in mammals is insufficient to restore
neurological function, illustrating the need to design better strategies for improving …