Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

V Thakur, S Bhola, P Thakur, SKS Patel, S Kulshrestha… - Infection, 2022 - Springer
The coronavirus disease-19 has left a permanent mark on the history of the human race.
Severe acute respiratory syndrome coronavirus-2 is a positive-sense single-stranded RNA …

Evolutionary trajectory of SARS-CoV-2 and emerging variants

J Singh, P Pandit, AG McArthur, A Banerjee… - Virology journal, 2021 - Springer
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …

[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness

JA Plante, Y Liu, J Liu, H Xia, BA Johnson… - Nature, 2021 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein
substitution D614G became dominant during the coronavirus disease 2019 (COVID-19) …

[HTML][HTML] Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus

B Korber, WM Fischer, S Gnanakaran, H Yoon… - Cell, 2020 - cell.com
A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become
the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies …

[HTML][HTML] Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity

E Volz, V Hill, JT McCrone, A Price, D Jorgensen… - Cell, 2021 - cell.com
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G
are suggestive of a selective advantage but may also be due to a random founder effect. We …

[HTML][HTML] Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear

ND Grubaugh, WP Hanage, AL Rasmussen - Cell, 2020 - cell.com
In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein
D614G rapidly became dominant around the world. Although clinical and in vitro data …

Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies

L Bian, F Gao, J Zhang, Q He, Q Mao, M Xu… - Expert review of …, 2021 - Taylor & Francis
Introduction As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic continues to spread, several variants have emerged. Variants B. 1.1. 7 and B …

Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area

SW Long, RJ Olsen, PA Christensen, DW Bernard… - MBio, 2020 - Am Soc Microbiol
We sequenced the genomes of 5,085 severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) strains causing two coronavirus disease 2019 (COVID-19) disease waves in …

The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design

DC Groves, SL Rowland-Jones, A Angyal - Biochemical and biophysical …, 2021 - Elsevier
The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide
sequencing effort to characterise the geographical spread and molecular evolution of the …

Implications of the novel mutations in the SARS-CoV-2 genome for transmission, disease severity, and the vaccine development

H Akkiz - Frontiers in medicine, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus of the
coronavirus disease 2019 (COVID-19), has been identified in China in late December 2019 …