Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and
progression of Parkinson's disease (PD). Glutathione (GSH) and the reduced/oxidized …

N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

The role of glutathione in autism spectrum disorder (ASD) is emerging as a major topic, due
to its role in the maintenance of the intracellular redox balance. Several studies have …

It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

Oxidative stress has long been linked to the neuronal cell death that is associated with
certain neurodegenerative conditions. Whether it is a primary cause or merely a downstream …

Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of
Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and α …

Animal models are important tools in experimental medical science to better understand
pathogenesis of human diseases. Once developed, these models can be exploited to test …