As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

Biomolecular condensates have emerged as an important subcellular organizing principle.
Replication of many viruses, including human respiratory syncytial virus (RSV), occurs in …

BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …

G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins in
the human genome and are important therapeutic targets. During the last decade, the …

INTRODUCTION Retinal is a light-sensitive protein ligand that is used by all domains of life
to process the information and energy content of light. Retinal-binding proteins are integral …

G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …

A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …

The SwissFEL X-ray Free Electron Laser (XFEL) facility started construction at the Paul
Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in …