Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are
widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain …

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

The G protein-coupled receptor APJ and its cognate ligand, apelin, are widely expressed
throughout human body. They are implicated in different key physiological processes such …

The Apelin/APJ system is involved in a wide range of biological functions. For a long time,
Apelin was thought to be the only ligand for APJ. Recently, a new peptide that acts via APJ …

Localization of apelin and its receptor APJ in limbic structures such as the hippocampus
suggests potential involvement of apelin/APJ signaling in stress-related emotional …

Apelin-13 in blood pressure regulation and cardiovascular di... : Current Opinion in Nephrology
and Hypertension Apelin-13 in blood pressure regulation and cardiovascular disease : Current …

Background Myocardial infarction (MI) significantly contributes to the global mortality rate,
often leading to heart failure (HF) due to left ventricular remodeling. Key factors in the …

Apelin and ELABELA (ELA), which are peptides belonging to the adipokines group, are
endogenous peptide ligands of their receptor, APJ, which together constitute the apelinergic …

Background Nonalcoholic fatty liver disease (NAFLD) represents one of the most common
forms of liver disease worldwide, and it is always regarded as a consequence of a …

The apelin receptor (APLNR) is a GPCR involved in many pathophysiological processes;
however, the correlation between APLNR expression and nasopharyngeal carcinoma …