SARS-CoV-2 viral load and shedding kinetics

O Puhach, B Meyer, I Eckerle - Nature Reviews Microbiology, 2023 - nature.com
SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two
key parameters for estimating infectiousness. As shedding of infectious virus is required for …

What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

SH Hodgson, K Mansatta, G Mallett, V Harris… - The lancet infectious …, 2021 - thelancet.com
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …

Estimating infectiousness throughout SARS-CoV-2 infection course

TC Jones, G Biele, B Mühlemann, T Veith, J Schneider… - Science, 2021 - science.org
INTRODUCTION Although post facto studies have revealed the importance of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from presymptomatic …

[PDF][PDF] Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective Cohort in Wuhan, China

L Liu, HG Chen, Y Li, H Li, J Li… - Eng …, 2021 - devp-service.oss-cn-beijing.aliyuncs …
abstract The longitudinal immunologic status of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)-infected patients and its association with the clinical outcome …

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

JJA van Kampen, DAMC van de Vijver… - Nature …, 2021 - nature.com
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …

Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies

BG Pijls, S Jolani, A Atherley, RT Derckx, JIR Dijkstra… - BMJ open, 2021 - bmjopen.bmj.com
Objective We aimed to describe the associations of age and sex with the risk of COVID-19 in
different severity stages ranging from infection to death. Design Systematic review and meta …

Rapid, point‐of‐care antigen tests for diagnosis of SARS‐CoV‐2 infection

J Dinnes, P Sharma, S Berhane… - Cochrane database …, 2022 - cochranelibrary.com
Background Accurate rapid diagnostic tests for SARS‐CoV‐2 infection would be a useful
tool to help manage the COVID‐19 pandemic. Testing strategies that use rapid antigen tests …

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

WS Lee, AK Wheatley, SJ Kent, BJ DeKosky - Nature microbiology, 2020 - nature.com
Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …

Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness

R Ke, PP Martinez, RL Smith, LL Gibson, A Mirza… - Nature …, 2022 - nature.com
The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly
understood. We captured the dynamics of infectious virus and viral RNA shedding during …

[HTML][HTML] SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

M Cevik, M Tate, O Lloyd, AE Maraolo, J Schafers… - The lancet …, 2021 - thelancet.com
Background Viral load kinetics and duration of viral shedding are important determinants for
disease transmission. We aimed to characterise viral load dynamics, duration of viral RNA …