There are two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs, with
other candidates, such as GPR55, PPARs and vanilloid TRPV1 (VR1) receptors, which are …

A large segment of the population suffers from addiction to alcohol, smoking, or illicit drugs.
Not only do substance abuse and addiction pose a threat to health, but the consequences of …

Tobacco smoking continues to be a leading cause of preventable death. Recent research
has underscored the important role of specific cholinergic nicotinic receptor subunit (CHRN) …

Genetic reference populations, particularly the BXD recombinant inbred (BXD RI) strains
derived from C57BL/6J and DBA/2J mice, are a valuable resource for the discovery of the …

Epidemiological and phenomenological studies suggest shared underpinnings between
multiple addictive behaviors. The present genetic association study was conducted as part …

Background We have used a genetical genomic approach, in conjunction with phenotypic
analysis of alcohol consumption, to identify candidate genes that predispose to varying …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

A clinician's effectiveness in treatment depends substantially on his or her attitude toward--
and understanding of--the patient as a person endowed with self-awareness and the will to …

Aim Twin studies have shown that cannabis use disorders (abuse/dependence) are highly
heritable. This review aims to:(i) review existing linkage studies of cannabis use disorders …

Alterations of brain structures have been seen in patients suffering from drug abuse or
mental disorders like schizophrenia. Similar changes in volume of brain structures have …