Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the
induction of cell cycle arrest and apoptosis by DNA damage. Insight into Chk2 has derived …

Abstract Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear
transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of …

In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple
cancer forms. The aberrant high levels observed in cancer tissue have been associated with …

Abstract Karyopherin alpha 2 (KPNA2), a member of the karyopherin family, has a central
role in nucleocytoplasmic transport and is overexpressed in many cancers. Our previous …

Nucleocytoplasmic transport is an essential cellular activity and occurs via nuclear pore
complexes (NPCs) that reside in the double membrane of the nuclear envelope. Significant …

Cisplatin is a known antitumor drug, but its mechanisms of action are not fully elucidated. In
this research, we studied the anticancer potential of cisplatin at doses of 1, 2, or 3 μM using …

Hypomorphic mutations of the MRE11 gene are the hallmark of the radiosensitive ataxia-
telangiectasia-like disorder (ATLD). Here, we describe a new family with two affected …

Background: It is recognised that modulations of the nuclear import of macromolecules have
a role in changing cellular phenotypes and carcinogenesis. We and others have noticed that …