Mitochondrial architecture is involved in several functions crucial for cell viability,
proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the …

Aging is associated with a decline in mitochondrial function and the accumulation of
abnormal mitochondria. However, the precise mechanisms by which aging promotes these …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act
as quality control mechanisms to ensure mitochondrial function and fine‐tune cellular …

Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major
contributors to aging. However, the molecular mechanisms responsible for these …

Abstract Charcot–Marie–Tooth disease (CMT) type 2A is a form of peripheral neuropathy,
due almost exclusively to dominant mutations in the nuclear gene encoding the …

Mfn2 is a mitochondrial fusion protein with bioenergetic functions implicated in the
pathophysiology of neuronal and metabolic disorders. Understanding the bioenergetic …

Background It is well acknowledged that alcoholic liver disease (ALD) is widely prevalent all
over the world, characterized by aberrant lipid deposition and excessive oxidative stress in …

Aim Mitochondria undergo continuous changes in shape as result of complex fusion and
fission processes. The physiological relevance of mitochondrial dynamics is still unclear. In …

Mitochondria are dynamic organelles engaged in quality control and aging processes. They
constantly undergo fusion, fission, transport, and anchoring events, which empower …