The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Abstract The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament
networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These
lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

The endocytic delivery of macromolecules from the mammalian cell surface for degradation
by lysosomal acid hydrolases requires traffic through early endosomes to late endosomes …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

In macropinocytosis, cells take up micrometre-sized droplets of medium into internal
vesicles. These vesicles are acidified and fused to lysosomes, their contents digested and …

ABSTRACT The vacuolar H+-ATPase (V-ATPase) has long been appreciated to function as
an electrogenic H+ pump. By altering the pH of intracellular compartments, the V-ATPase …