Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared
with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been …

Most cardiovascular diseases (CVDs), as well as age-related cardiovascular alterations, are
accompanied by increases in oxidative stress, usually due to increased generation and/or …

Advanced age is an independent risk factor for ageing-related complex diseases, such as
coronary artery disease, stroke, and hypertension, which are common but life threatening …

Reactive oxygen species (ROS) act as signaling molecules that control physiological
processes, including cell adaptation to stress. Redox signaling via ROS has quite recently …

Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the
release of GH. It is a first hormone linking gastrointestinal-pituitary axis. Objective: This …

Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions
are associated with increased risk for the development of other comorbidities and obesity …

The only molecularly identified ghrelin receptor is the growth hormone secretagogue
receptor GHSR1a. Its natural ligand, ghrelin, is an acylated peptide whose unacylated …

Ghrelin is a stomach‐derived octanoylated peptide hormone that plays a variety of well‐
established biological roles acting via its specific receptor known as growth hormone …

Background There is increasing evidence that unacylated ghrelin (UAG) improves insulin
sensitivity and glucose homeostasis; however, the mechanism for this activity is not fully …

Context: Ghrelin is an endogenous stimulator of GH and is implicated in a number of
physiological processes. Clinical trials have been performed in a variety of patient …