Cyclosporin is a lipophilic cyclic polypeptide which produces calcium-dependent, specific,
reversible inhibition of transcription of interleukin-2 and several other cytokines, most …

Cyclosporin is a powerful immunosuppressive drug used in transplantation medicine and to
treat autoimmune diseases. It is a lipophilic molecule, with its bioavailability dependent on …

Background: Therapeutic drug monitoring (TDM) is essential to maintain the efficacy of many
immunosuppressant drugs while minimizing their toxicity. TDM has become more refined …

Objective To characterize the pharmacokinetics of the immunosuppressive agent tacrolimus
(FK 506) in liver transplant patients. Methods Patients (n= 16) were assessed during and …

Synopsis The microemulsion-basedformulation of cyclosporin (Neoral®; referred to as the
microemulsion formulation in this review) is a microemulsion preconcentrate which has …

Purpose To apply physiologically-based pharmacokinetic (PBPK) modeling to investigate
the consequences of reduction in activity of hepatic and intestinal uptake and efflux …

This cross-over study compared the pharmacokinetic parameters obtained from
cyclosporine (CsA) concentration-time profiles after administration of the corn oil-based soft …

The calcineurin inhibitors cyclosporine and tacrolimus form the cornerstones of most
immunosuppression protocols. Because of their variable pharmacokinetics, and their narrow …

Background: Immunoassays designed for the selective measurement of cyclosporin A (CsA)
inadvertently show cross-reactivity for CsA metabolites. The extent and clinical significance …

Publisher Summary The powerful immunosuppressive activity of ciclosporin (CS), which is
apparently restricted at the cellular level of certain T lymphocytes, is recognized as a …