Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Cancer is the most common cause of death worldwide, following cardiovascular diseases.
Cancer is a multifactorial disease and many reasons such as physical, chemical, biological …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

If aging is due to or contributed by free radical reactions, as postulated by the free radical
theory of aging, lifespan of organisms should be extended by administration of exogenous …

The function of one-carbon metabolism is that of regulating the provision of methyl groups
for biological methylation reactions including that of DNA and histone proteins. Methylation …

The desire of eternal youth seems to be as old as mankind. However, the increasing life
expectancy experienced by populations in developed countries also involves a significantly …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Mediterranean diet has been proposed to promote healthy aging, but its effects on aging
biomarkers have been poorly investigated. We evaluated the impact of a 1-year …