The chemotherapy currently available for leishmaniasis is far from satisfactory. Resistance to
the pentavalent antimonials, which have been the recommended drugs for the treatment of …

The trypanosomiases consist of a group of important animal and human diseases caused by
parasitic protozoa of the genus Trypanosoma. In sub-Saharan Africa, the final decade of the …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Fructose 1, 6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the
fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and …

Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

Background The dynamics of the cellular glycolysis pathway underpin cellular function and
dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies …

Proline metabolism has been studied in procyclic form Trypanosoma brucei. These
parasites consume six times more proline from the medium when glucose is in limiting …

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe
the metabolic pathways active in cultured bloodstream form trypomastigotes of …

Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement
and fatal systemic infection. WHO estimates that the disease results in 2 million new cases a …

A mathematical model of glycolysis in bloodstream form Trypanosoma brucei was
developed previously on the basis of all available enzyme kinetic data (Bakker, BM, Michels …