Abstract Reactome (http://www. reactome. org) is an open‐source, expert‐authored, peer‐
reviewed, manually curated database of reactions, pathways and biological processes. We …

Targeting protein quality control (PQC) pathways using proteasome or p97/VCP inhibition
can effectively treat blood tumors. However, in solid tumors, only p97/VCP inhibitors are …

Single‐allele study designs, commonly used in genome‐wide association studies (GWAS)
as well as the more recently developed whole genome sequencing (WGS) studies, are a …

Background Visual perception is initiated in the photoreceptor cells of the retina via the
phototransduction system. This system has shown marked evolution during mammalian …

Abstract Background Asparagine N-Glycosylation is one of the most important forms of
protein post-translational modification in eukaryotes. This metabolic pathway can be …

Genome‐wide association studies (GWAS) are a standard approach for investigating the
relationship of common variation within the human genome to a given phenotype of interest …

This book summarizes the knowledge in the field of methods to identify signatures of natural
selection. A number of mathematical models and methods have been designed to identify …

A aterosclerose é uma condição patológica crônica e inflamatória que afeta artérias de
grande e médio calibre e representa um risco para desfechos clínicos como infarto do …

C12N15/113—Non-coding nucleic acids modulating the expression of genes, eg antisense
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …

The difficulty in the functional understanding of the genome lies not only in the high number
of functional elements but also in the fact that they interact in entangled pathways, giving rise …