Sphingolipid levels and signaling via resveratrol and antioxidant actions in cardiometabolic risk and disease

M Gaggini, S Fenizia, C Vassalle - Antioxidants, 2023 - mdpi.com
Resveratrol (RSV) is a phenolic compound with strong antioxidant activity, which is
generally associated with the beneficial effects of wine on human health. All resveratrol …

A rationale for hypoxic and chemical conditioning in Huntington's disease

J Burtscher, V Maglione, A Di Pardo, GP Millet… - International Journal of …, 2021 - mdpi.com
Neurodegenerative diseases are characterized by adverse cellular environments and
pathological alterations causing neurodegeneration in distinct brain regions. This …

Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

Z Pan, Y Hu, Z Huang, N Han, Y Li, X Zhuang… - Science China Life …, 2022 - Springer
The gut microbiota is involved in host responses to high altitude. However, the dynamics of
intestinal microecology and their association with altitude-related illness are poorly …

Link between serum lipid signature and prognostic factors in COVID-19 patients

M Dei Cas, S Ottolenghi, C Morano, R Rinaldo… - Scientific Reports, 2021 - nature.com
Although the serum lipidome is markedly affected by COVID-19, two unresolved issues
remain: how the severity of the disease affects the level and the composition of serum lipids …

Differential redox state and iron regulation in chronic obstructive pulmonary disease, acute respiratory distress syndrome and coronavirus disease 2019

L Duca, S Ottolenghi, S Coppola, R Rinaldo, M Dei Cas… - Antioxidants, 2021 - mdpi.com
In patients affected by Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive
Pulmonary Disease (COPD) and Coronavirus Disease 2019 (COVID-19), unclear …

Tibetan medicine Duoxuekang ameliorates hypobaric hypoxia-induced brain injury in mice by restoration of cerebrovascular function

N Li, K Chen, J Bai, Z Geng, Y Tang, Y Hou… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Duoxuekang (DXK, ཁྲག་ འཕེལ་ བདེ་ བྱེད།) is a
clinical experience prescription of CuoRu-Cailang, a famous Tibetan medicine master …

Redox modification of ryanodine receptor contributes to impaired Ca2+ homeostasis and exacerbates muscle atrophy under high altitude

A Agrawal, R Rathor, R Kumar, G Suryakumar… - Free Radical Biology …, 2020 - Elsevier
At extreme altitude, prolonged and severe hypoxia menaces human function and survival,
and also associated with profound loss of muscle mass which results into a debilitating …

Longitudinal multi-omics analysis uncovers the altered landscape of gut microbiota and plasma metabolome in response to high altitude

Y Han, X Liu, Q Jia, J Xu, J Shi, X Li, G Xie, X Zhao… - Microbiome, 2024 - Springer
Background Gut microbiota is significantly influenced by altitude. However, the dynamics of
gut microbiota in relation to altitude remains undisclosed. Methods In this study, we …

Sphingosine 1-phosphate in sepsis and beyond: its role in disease tolerance and host defense and the impact of carrier molecules

AC Ziegler, T Müller, MH Gräler - Cellular Signalling, 2021 - Elsevier
Abstract Sphingosine 1-phosphate (S1P) is an important immune modulator responsible for
physiological cellular responses like lymphocyte development and function, positioning and …

ROS responsive silica nanoparticles for controlled and targeted drug delivery

D Prajapati, A Patani, T Jain, A Patel… - Smart nanomaterials …, 2023 - Springer
Reactive oxygen species (ROS) have an important role in biological metabolism and
intercellular communication pathways in living beings. ROS are involved in numerous …