Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of
risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of …

Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of
pancreatic cancer, with a survival approaching only 11% at five years after diagnosis. In the …

Background Early-onset pancreatic cancer (EOPC) represents 5–10% of all pancreatic
ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It …

Genes carrying high‐penetrance germline mutations may also be associated with cancer
susceptibility through common low‐penetrance genetic variants. To increase the knowledge …

Introduction Only a small number of risk factors for pancreatic ductal adenocarcinoma
(PDAC) has been established. Several studies identified a role of epigenetics and of …

Introduction Pancreatic ductal adenocarcinoma (PDAC) is lethal due to its late diagnosis
and lack of successful treatments. A possible strategy to reduce its death burden is …

Coding sequence variants comprise a small fraction of the germline genetic variability of the
human genome. However, they often cause deleterious change in protein function and are …

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is
unresponsive to conventional therapeutic modalities due to its high heterogeneity …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients
having unresectable or metastatic disease at diagnosis, with poor prognosis and very short …

Correlated regions of systemic interindividual variation (CoRSIV) represent a small
proportion of the human genome showing DNA methylation patterns that are the same in all …