Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …

To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed
by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from …

Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive
inherited Parkinson's disease (PD). We have exploited our recent discovery that …

Cells keep their energy balance and avoid oxidative stress by regulating mitochondrial
movement, distribution, and clearance. We report here that two Parkinson's disease …

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and
mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the …

Mitochondria have a number of essential roles in neuronal function. Their complex mobility
patterns within neurons are characterized by frequent changes in direction. Mobile …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …