VKORC1 and CYP2C9 genotype distribution in Asian countries
T Gaikwad, K Ghosh, S Shetty - Thrombosis research, 2014 - Elsevier
Background Warfarin is the most widely used anticoagulant all over the world for prevention
and treatment of different thrombotic conditions. Polymorphisms in two genes ie CYP2C9 …
and treatment of different thrombotic conditions. Polymorphisms in two genes ie CYP2C9 …
PharmGKB summary: very important pharmacogene information for CYP4F2
ML Alvarellos, K Sangkuhl, R Daneshjou… - Pharmacogenetics …, 2015 - journals.lww.com
Introduction Cytochrome p450, family 2, subfamily F, polypeptide 2 (CYP4F2) catalyzes the
NADPH-dependent oxidation of the terminal carbon of long and very long chain fatty acids …
NADPH-dependent oxidation of the terminal carbon of long and very long chain fatty acids …
[HTML][HTML] A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients
J Chen, L Shao, L Gong, F Luo, J Wang, Y Shi, Y Tan… - PLoS …, 2014 - journals.plos.org
Inconsistent associations with warfarin dose were observed in genetic variants except
VKORC1 haplotype and CYP2C9* 3 in Chinese people, and few studies on warfarin dose …
VKORC1 haplotype and CYP2C9* 3 in Chinese people, and few studies on warfarin dose …
Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy
YB Jarrar, SJ Lee - Drug metabolism and drug interactions, 2014 - degruyter.com
Abstract CYP2C9 metabolizes approximately 20% of clinically used drugs, including the
narrow therapeutic window drugs warfarin and phenytoin. More than 16,000 variants have …
narrow therapeutic window drugs warfarin and phenytoin. More than 16,000 variants have …
Pharmacogenomics in Asia: a systematic review on current trends and novel discoveries
While early pharmacogenomic studies have primarily been carried out in Western
populations, there has been a notable increase in the number of Asian studies over the past …
populations, there has been a notable increase in the number of Asian studies over the past …
Frequency of common VKORC1 polymorphisms and their impact on warfarin dose requirement in Pakistani population
Polymorphisms in vitamin K epoxide reductase complex subunit 1 (VKORC1) gene lead to
interindividual variability in warfarin dose requirement. The characterization of genotype …
interindividual variability in warfarin dose requirement. The characterization of genotype …
Validation of a proposed warfarin dosing algorithm based on the genetic make-up of Egyptian patients
Background Warfarin is the most frequently prescribed oral anticoagulant worldwide. Due to
its narrow therapeutic index and inter-patient variability in dose requirement, this drug has …
its narrow therapeutic index and inter-patient variability in dose requirement, this drug has …
The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies
Context Co-administration between warfarin (WF) and Curcuma xanthorrhiza
Roxb.(Zingiberaceae)(CX) is found in Indonesian patients and need to be evaluated …
Roxb.(Zingiberaceae)(CX) is found in Indonesian patients and need to be evaluated …
Is There a Role for MDR1, EPHX1 and Protein Z Gene Variants in Modulation of Warfarin Dosage? A Study on a Cohort of the Egyptian Population
MSM Issac, MS El-Nahid, MY Wissa - Molecular diagnosis & therapy, 2014 - Springer
Background There is considerable inter-individual variability in warfarin dosages necessary
to achieve target therapeutic anticoagulation. Polymorphisms in genes, which master …
to achieve target therapeutic anticoagulation. Polymorphisms in genes, which master …
Effect of CYP2C9 and VKORC1 genetic polymorphisms on mean daily maintenance dose of acenocoumarol in South Indian patients
DK Kumar, S Madhan, J Balachander… - Thrombosis research, 2013 - Elsevier
AIM: To determine the effect of CYP2C9 and VKORC1 genetic polymorphisms on mean
daily maintenance dose of acenocoumarol in South Indian patients with heart valve …
daily maintenance dose of acenocoumarol in South Indian patients with heart valve …