Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Developing and testing of lipid force fields with applications to modeling cellular membranes
The amphipathic nature of the lipid molecule (hydrophilic head and hydrophobic tails)
enables it to act as a barrier between fluids with various properties and to sustain an …
enables it to act as a barrier between fluids with various properties and to sustain an …
Wrapping anisotropic microgel particles in lipid membranes: Effects of particle shape and membrane rigidity
Cellular engulfment and uptake of macromolecular assemblies or nanoparticles via
endocytosis can be associated to both healthy and disease-related biological processes as …
endocytosis can be associated to both healthy and disease-related biological processes as …
Molecular dynamics for antimicrobial peptide discovery
Although antimicrobial resistance is an increasingly significant public health concern, there
have only been two new classes of antibiotics approved for human use since the 1960s …
have only been two new classes of antibiotics approved for human use since the 1960s …
Flipped C-terminal ends of apoA1 promote ABCA1-dependent cholesterol efflux by small HDLs
Y He, C Pavanello, PM Hutchins, C Tang… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Cholesterol efflux capacity (CEC) predicts cardiovascular disease
independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL …
independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL …
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
High-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and
suppress inflammation, but their utility in treating EC dysfunction has not been fully explored …
suppress inflammation, but their utility in treating EC dysfunction has not been fully explored …
[HTML][HTML] Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly
M Gimenez-Andres, T Emeršič, S Antoine-Bally… - Elife, 2021 - elifesciences.org
Numerous proteins target lipid droplets (LDs) through amphipathic helices (AHs). It is
generally assumed that AHs insert bulky hydrophobic residues in packing defects at the LD …
generally assumed that AHs insert bulky hydrophobic residues in packing defects at the LD …
[HTML][HTML] Artificial high density lipoprotein nanoparticles in cardiovascular research
K Kornmueller, I Vidakovic, R Prassl - Molecules, 2019 - mdpi.com
Lipoproteins are endogenous nanoparticles which are the major transporter of fats and
cholesterol in the human body. They play a key role in the regulatory mechanisms of …
cholesterol in the human body. They play a key role in the regulatory mechanisms of …
Confinement in nanodiscs anisotropically modifies lipid bilayer elastic properties
I Schachter, C Allolio, G Khelashvili… - The Journal of Physical …, 2020 - ACS Publications
Lipid nanodiscs are small synthetic lipid bilayer structures that are stabilized in solution by
special circumscribing (or scaffolding) proteins or polymers. Because they create native-like …
special circumscribing (or scaffolding) proteins or polymers. Because they create native-like …
Reconfigurable peptide analogs of apolipoprotein ai reveal tunable features of nanodisc assembly
Nanodisc (ND)-forming membrane scaffold proteins or peptides developed from
apolipoprotein AI (apoA-I) have led to considerable promise in structural biology and …
apolipoprotein AI (apoA-I) have led to considerable promise in structural biology and …