Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Abstract Background Lecanemab (BAN2401), an IgG1 monoclonal antibody, preferentially
targets soluble aggregated amyloid beta (Aβ), with activity across oligomers, protofibrils, and …

Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Fluorescence imaging in the second near‐infrared (NIR‐II) window holds great promise for
in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and …

Amyloids are implicated in neurodegenerative diseases. Fibrillar aggregates of the amyloid-
β protein (Aβ) are the main component of the senile plaques found in brains of Alzheimer's …

This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

Polymerization and phase separation of proteins containing low-complexity (LC) domains
are important factors in gene expression, mRNA processing and trafficking, and localization …