Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment

Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023 - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review

MS Hussain, G Gupta, M Afzal, SM Alqahtani… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression,
contributing significantly to a diverse range of cellular processes, including apoptosis. One …

Present and future perspective on PLK1 inhibition in cancer treatment

M Chiappa, S Petrella, G Damia, M Broggini… - Frontiers in …, 2022 - frontiersin.org
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …

Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents?

A Gielecińska, M Kciuk, EB Yahya, T Ainane… - … et Biophysica Acta (BBA …, 2023 - Elsevier
For decades, common chemotherapeutic drugs have been established to trigger apoptosis,
the preferred immunologically “silent” form of cell death. The primary objective of this review …

Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions

HS Tuli, R Joshi, G Kaur, VK Garg, K Sak… - Journal of Nanostructure …, 2023 - Springer
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for
therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) …

Organelle‐specific mechanisms in crosstalk between apoptosis and ferroptosis

P Wu, X Zhang, D Duan, L Zhao - Oxidative Medicine and …, 2023 - Wiley Online Library
Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of
regulated cell death that involves iron‐dependent accumulations of lipid hydroperoxides …

Anti-inflammatory and anticancer properties of birch bark-derived betulin: recent developments

HS Tuli, K Sak, DS Gupta, G Kaur, D Aggarwal… - Plants, 2021 - mdpi.com
Birch tree bark-derived betulin has attracted scientific interest already for several centuries,
being one of the first natural products identified from plants. However, the cellular events …

Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells

N Rai, P Gupta, A Verma, SK Singh, V Gautam - BioFactors, 2023 - Wiley Online Library
Endophytic fungi are a well‐established reservoir of bioactive compounds that are
pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The …

Programmed cell death in asthma: apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis

L Liu, L Zhou, LL Wang, PD Zheng… - Journal of …, 2023 - Taylor & Francis
Bronchial asthma is a complex heterogeneous airway disease, which has emerged as a
global health issue. A comprehensive understanding of the different molecular mechanisms …

Molecular mechanism of palmitic acid and its derivatives in tumor progression

X Wang, C Zhang, N Bao - Frontiers in oncology, 2023 - frontiersin.org
Palmitic acid (PA) is a saturated fatty acid commonly found in coconut oil and palm oil. It
serves as an energy source for the body and plays a role in the structure and function of cell …