Over the last few decades, Drosophila cancer models have made great contributions to our
understanding toward fundamental cancer processes. Particularly, the development of …

This review presents the accumulating evidence for the roles of protein phosphatase 6 (PP6)
in cell cycle, DNA damage repair, inflammatory signaling, lymphocyte development, virus …

Activation of TNFR1 by TNFα induces the formation of a membrane-associated, intracellular
complex termed complex I. Complex I orchestrates a complex pattern of modifications on key …

Cancer metastasis causes over 90% of cancer patient fatalities. Poor prognosis is
determined by tumor type, the tumor microenvironment (TME), organ-specific biology, and …

Protein phosphorylation is an essential regulatory mechanism that controls most cellular
processes, including cell cycle progression, cell division, and response to extracellular …

Black bean seed coat extract (BBSCE) contains a high amount of bioactive compounds
which can reduce the risk of cancers, but the underlying mechanism remains poorly …

Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting
on the core components of the pathway. Despite being an established drug target and a hub …

Unfolded protein response (UPR) is the mechanism by which cells control endoplasmic
reticulum (ER) protein homeostasis. ER proteostasis is essential to adapt to cell proliferation …

Ovarian cancer is the most common gynecological malignancy that causes cancer-related
deaths in women today; this being the case, developing an understanding of ovarian cancer …

The development of human metastatic cancer is a multistep process, involving the
acquisition of several genetic mutations, tumour heterogeneity, and interactions with the …