The traditional drug discovery pipeline for the identification and development of compounds
that selectively target specific molecules to ameliorate disease remains a major focus for …

MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets
and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be …

Developmental exposure to neurotoxic chemicals presents significant health concerns
because of the vulnerability of the developing central nervous system (CNS) and the …

High levels of reactive oxygen species (ROS) may cause a change of cellular redox state
towards oxidative stress condition. This situation causes oxidation of molecules (lipid, DNA …

Clethodim is one of the most widely used herbicides in agriculture, however, its potential
toxic effects on organisms and the underlying toxicity mechanism are still poorly understood …

Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent
models, including low maintenance and husbandry costs, high fecundity, genetic diversity …

Macroautophagy (hereafter called autophagy) is an essential physiological process of
degradation of organelles and long-lived proteins. The discovery of autosis, a Na+/K+ …

Cardiotonic steroids (CTS) are a class of specific ligands of the Na+, K+-ATPase (NKA). NKA
is a P-type ATPase that is ubiquitously expressed and although well known to be …

Parkinson's disease (PD) is known as a movement disorder due to characteristic motor
features. Existing therapies for PD are only symptomatic, and their efficacy decreases as …

Parkinson's Disease (PD) is one of the most common neurodegenerative disorders that
affects the motor system, and includes cardinal motor symptoms such as resting tremor …