Terpenoids' anti-cancer effects: Focus on autophagy

C El-Baba, A Baassiri, G Kiriako, B Dia, S Fadlallah… - Apoptosis, 2021 - Springer
Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

Platycodon grandiflorum (Jacq.) A. DC.: A review of phytochemistry, pharmacology, toxicology and traditional use

S Zhang, X Chai, G Hou, F Zhao, Q Meng - Phytomedicine, 2022 - Elsevier
Abstract Background The traditional Chinese medicine Platycodon grandiflorum (Jacq.) A.
DC.(PG, balloon flower) has medicinal and culinary value. It consists of a variety of chemical …

Saponins from Chinese medicines as anticancer agents

XH Xu, T Li, CMV Fong, X Chen, XJ Chen, YT Wang… - Molecules, 2016 - mdpi.com
Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various
pharmacological effects against mammalian diseases. To promote the research and …

Killing cancer with platycodin D through multiple mechanisms

M Khan, A Maryam, H Zhang… - Journal of cellular and …, 2016 - Wiley Online Library
Cancer is a multi‐faceted disease comprised of a combination of genetic, epigenetic,
metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell …

Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms

Q Liu, JJ Lu, HJ Hong, Q Yang, Y Wang, XJ Chen - Phytomedicine, 2023 - Elsevier
Abstract Background Ophiopogon japonicus (Thunb.) Ker Gawl., a well-known Chinese
herb, has been used in traditional Chinese medicine for thousands of years. Extensive in …

Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics

LL Zhang, MY Huang, Y Yang, MQ Huang, JJ Shi… - Food chemistry, 2020 - Elsevier
Platycodonis Radix, the root of Platycodon grandiflorum (Jacq.) A. DC., is a well-known
edible herbal medicine. It is a common vegetable used for the preparation of side dish …

Non-apoptotic cell death in malignant tumor cells and natural compounds

J Ye, R Zhang, F Wu, L Zhai, K Wang, M Xiao, T Xie… - Cancer letters, 2018 - Elsevier
Traditional cancer therapy is mainly targeting on enhancing cell apoptosis, however, it is
well established that many cancer cells are chemo-resistant and defective in apoptosis …

Recent progress in understanding the action of natural compounds at novel therapeutic drug targets for the treatment of liver cancer

Y Zheng, W Zhang, L Xu, H Zhou, M Yuan… - Frontiers in …, 2022 - frontiersin.org
Liver cancer is the third most common cause of cancer-related death following lung and
stomach cancers. As a highly lethal disease, liver cancer is diagnosed frequently in less …

Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation

SJ Lee, YJ Choi, HI Kim, HE Moon, SH Paek… - Molecular …, 2022 - Wiley Online Library
Targeting autophagy is a promising therapeutic approach in cancer therapy. Here, we
screened 30 traditional herbal medicines to identify novel autophagy regulators and found …

Distribution, biotransformation, pharmacological effects, metabolic mechanism and safety evaluation of Platycodin D: A comprehensive review

Q Li, T Yang, S Zhao, Q Zheng, Y Li… - Current Drug …, 2022 - ingentaconnect.com
Platycodonis Radix (Jiegeng), the dried root of Platycodon grandiflorum, is a traditional herb
used as both medicine and food. Its clinical application for the treatment of cough, phlegm …