Cross-feeding in the gut microbiome: ecology and mechanisms

EJ Culp, AL Goodman - Cell host & microbe, 2023 - cell.com
Microbial communities are shaped by positive and negative interactions ranging from
competition to mutualism. In the context of the mammalian gut and its microbial inhabitants …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

Statistically learning the functional landscape of microbial communities

A Skwara, K Gowda, M Yousef… - Nature ecology & …, 2023 - nature.com
Microbial consortia exhibit complex functional properties in contexts ranging from soils to
bioreactors to human hosts. Understanding how community composition determines …

Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut

N Quinn-Bohmann, T Wilmanski, KR Sarmiento… - Nature …, 2024 - nature.com
Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to
host metabolism, immune regulation and integrity of the intestinal epithelium. However, the …

In vitro interaction network of a synthetic gut bacterial community

AS Weiss, AG Burrichter, AC Durai Raj… - The ISME …, 2022 - academic.oup.com
A key challenge in microbiome research is to predict the functionality of microbial
communities based on community membership and (meta)-genomic data. As central …

Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions

RA Oliveira, EG Pamer - Cell Host & Microbe, 2023 - cell.com
Increasing experimental evidence suggests that administering live commensal bacterial
species can optimize microbiome composition and lead to reduced disease severity and …

Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications

PT van Leeuwen, S Brul, J Zhang… - FEMS microbiology …, 2023 - academic.oup.com
The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

Short-chain fatty acids: linking diet, the microbiome and immunity

ER Mann, YK Lam, HH Uhlig - Nature Reviews Immunology, 2024 - nature.com
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

Massively parallel single-cell sequencing of diverse microbial populations

F Lan, J Saba, TD Ross, Z Zhou, K Krauska… - Nature …, 2024 - nature.com
Single-cell genetic heterogeneity is ubiquitous in microbial populations and an important
aspect of microbial biology; however, we lack a broadly applicable and accessible method …

The community-function landscape of microbial consortia

A Sanchez, D Bajic, J Diaz-Colunga, A Skwara… - Cell Systems, 2023 - cell.com
Quantitatively linking the composition and function of microbial communities is a major
aspiration of microbial ecology. Microbial community functions emerge from a complex web …