Here we review studies that provided important information about conformational properties
of DNA using circular dichroic (CD) spectroscopy. The conformational properties include the …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

The discovery of cisplatin (cis-Pt (NH 3) 2 Cl 2) as an antineoplastic agent has focussed
attention on the rational design of metal complexes that can be potentially used in cancer …

Thioflavin T (ThT) becomes fluorescent in the presence of the G-quadruplex structure such
as that formed by the human telomeric motif. In this report, we extend and generalize these …

G‐quadruplexes are four‐stranded nucleic acid structures whose biological functions
remain poorly understood. In the yeast S. cerevisia e, we report that G‐quadruplexes form …

Conspectus Compared with organic small molecules, metal complexes offer several distinct
advantages as therapeutic agents or biomolecular probes. Carbon atoms are typically …

Phen‐DC3 is a highly promising compound that specifically targets G‐quadruplexes, with
potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …