Dexmedetomidine is an α 2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic,
and analgesic-sparing effects, and minimal depression of respiratory function. It is potent …

Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …

Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human
exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of …

Carvacrol is a monoterpenic phenol produced by an abundant number of aromatic plants,
including thyme and oregano. Presently, carvacrol is used in low concentrations as a food …

Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute,
sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often …

Increasing evidence has highlighted the critical role of early life environment in shaping the
future health outcomes of an individual. Moreover, recent studies have revealed that early …

The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …

Background Polyvinyl chloride plastics (PVC), made flexible through the addition of di‐2‐
ethylhexyl phthalate (DEHP), are used in the production of a wide array of medical devices …

Growth and development are two major aspects of children not readily apparent in adults.
Clearance in the paediatric population should be investigated using models that describe …

UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …