Zinc is an important trace element in biology. An important pool of zinc in the brain is the one
present in synaptic vesicles in a subgroup of glutamatergic neurons. In this form it can be …

Publisher Summary This chapter highlights NF-кB/Rel protein complex. Associations of the
binding and regulatory subunits of NF-кB operate at the center of a variety of different signal …

The activation of nuclear factor kappa B (NF-kappa B) has been implicated in the regulation
of transcription of a variety of genes and has been shown to be essential for the expression …

During the development of an organism different patterns of active genes are established in
the nuclei of differentiating cells. These specific gene patterns are translated into distinct …

The pathogenesis of central nervous system (CNS) disease in acquired immunodeficiency
syndrome (AIDS) is poorly understood but may be related to specific effects of the immune …

IBD treatment is undergoing a transformation with an expanding repertoire of drugs targeting
different aspects of the immune response. Three novel classes of drugs have emerged in the …

The pathogenesis of the dementia associated with human immunodeficieny virus (HIV)
infection is unclear, but has been postulated to be due to indirect effects of HIV infection …

Microglia, macrophage‐like cells in the CNS, are multifunctional cells; they play an important
role in removal of dead cells or their remnants by phagocytosis in the CNS degeneration …

The role of NF‐kappa B‐dependent signals in activating the transcriptional activity of the HIV
regulatory region (LTR) was analyzed by systematic comparison of HIV LTR activity in …

Objective: HIV causes inflammation that can be at least partially corrected by HAART. To
determine the qualitative and quantitative nature of cytokine perturbation, we compared …