Effects of the size and concentration of depleting agents on the stabilization of the double-helix structure and DNA condensation: A single molecule force spectroscopy …

RM de Oliveira, MS Rocha - Chemical Physics Letters, 2024 - Elsevier
We perform a single molecule force spectroscopy study to characterize the role of the size
(molecular weight) and concentration of depleting agents on DNA condensation and on the …

[HTML][HTML] A cooperative transition from the semi-flexible to the flexible regime of polymer elasticity: mitoxantrone-induced DNA condensation

CHM Lima, GO Almeida, MS Rocha - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
We report a high cooperative transition from the semi-flexible to the flexible regime of
polymer elasticity during the interaction of the DNA molecule with the chemotherapeutic …

-Cyclodextrin polymer binding to DNA: Modulating the physicochemical parameters

JCB Rocha, EF Silva, MF Oliveira, FB Sousa… - Physical Review E, 2017 - APS
Cyclodextrins and cyclodextrins-modified molecules have interesting and appealing
properties due to their capacity to host components that are normally insoluble or poorly …

Doxorubicin hinders DNA condensation promoted by the protein bovine serum albumin (BSA)

CHM Lima, HMC de Paula, LHM da Silva… - …, 2017 - Wiley Online Library
In this work, we have studied the interaction between the anticancer drug doxorubicin (doxo)
and condensed DNA, using optical tweezers. To perform this task, we use the protein bovine …

Force Spectroscopy of the Frameshift Signal from West Nile Virus Reveals Multiple Folding Pathways and Structural Heterogeneity

MT Halma, DB Ritchie, MT Woodside - Biophysical Journal, 2019 - cell.com
Ribosomal translocation is a high fidelity process, in which the ribosome scanned exactly 3
nucleotides to decoding the next codon. Because there is no gap between codons, errors …