Publisher Summary This chapter provides an overview of the properties of mature thymus-
derived (T) cells, including both the molecules they use for recognition and the molecules …

Abstract Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb)
has been shown to suppress growth of a variety of different tumours in mice. These studies …

An efficacious vaccine strategy must be capable of inducing strong responses of an
appropriate phenotype that are long lasting and sufficiently broad to prevent pathogen …

Caspases play a central role in T lymphocyte activation and death. We have demonstrated
previously that caspase-3, an effector molecule for activation-induced cell death (AICD), is …

Although IL-4 and IFN-γ often have opposite effects and suppress each other's production by
T cells, IL-4 can stimulate IFN-γ production. To characterize this, we injected mice with IL-4 …

Background. Quadruple immunosuppressive induction therapy has been shown to markedly
reduce the incidence of acute rejection episodes without increasing the incidence of …

Interleukin-2 can induce cytolytic activity in human peripheral blood lymphocytes and this
activation is mediated by the beta chain of the interleukin-2 receptor-beta (IL-2R beta) …

We have previously shown that unlike endogenous ϰ genes, unrearranged ϰ transgenes
undergo Vϰ‐Jϰ recombination in T as well as B cells of transgenic mice. To determine …

In this study, we have investigated the expression of the α and β chains of the IL-2 receptor
(IL-2Rα, IL-2Rβ) both at the membrane and at transcrlptlonal levels during the lifespan of …

Abstract An interleukin (IL)‐4 dependant mouse T cell clone 8.2 derived from an IL‐2‐
dependent T cell line was characterized. As measured by flow cytometric analysis and …