[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Regulation of gene expression by cis-acting long non-coding RNAs
N Gil, I Ulitsky - Nature Reviews Genetics, 2020 - nature.com
Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …
Tumor immune microenvironment lncRNAs
EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …
immune responses. The nature of their cell type-specific gene expression and other …
The multidimensional mechanisms of long noncoding RNA function
A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …
apparent that the majority of cellular transcripts do not code for proteins, and many of them …
Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis
Inflammation is a risk factor for cancer development. Individuals with preleukemic TET2
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …
Programmed cell death and the immune system
S Nagata, M Tanaka - Nature Reviews Immunology, 2017 - nature.com
More than 50 years ago, cells were observed to die during insect development via a process
that was named'programmed cell death'. Later, a similar cell death process was found to …
that was named'programmed cell death'. Later, a similar cell death process was found to …
Contributions of eosinophils to human health and disease
AD Klion, SJ Ackerman… - Annual Review of …, 2020 - annualreviews.org
The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …
immunity but at times has also been incriminated in disease pathophysiology. Research into …