Nanotechnology research over the past several decades has been aimed primarily at
improving the physicochemical properties of small molecules to produce druggable …

The liver is the metabolic center of the body and an ideal target for gene therapy of inherited
metabolic disorders (IMDs). Adeno‐associated viral (AAV) vectors can deliver transgenes to …

Rotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the
synthesis of virus genome segments and their encapsidation in the core shell, followed by …

Today, adeno-associated virus (AAV)-based vectors are arguably the most promising in vivo
gene delivery vehicles for durable therapeutic gene expression. Advances in molecular …

Adeno-associated virus (AAV) vectors have emerged as the leading delivery platforms for
gene therapy. Throughout the life cycle of the virions, the capsid vector carries out diverse …

We determined the transcription profile of adeno-associated virus type 2 (AAV2)-infected
primary human fibroblasts. Subsequent analysis revealed that cells respond to AAV infection …

Research on adeno-associated virus (AAV) and its recombinant vectors as well as on
fluorescence microscopy imaging is rapidly progressing driven by clinical applications and …

All current market-approved gene therapy medical products for in vivo gene therapy of
monogenic diseases rely on adeno-associated virus (AAV) vectors. Advances in gene …

A hypothesis of Alzheimer's disease etiology is proposed describing how cellular stress
induces excessive polyamine synthesis and recycling which can disrupt nucleoli …

Adeno-associated viruses (AAVs) are commonly used vectors for DNA delivery in gene
therapy. Here we developed a system that enables the AAV shell to package mRNAs by …