Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …

There are four members of the EGFR family: EGFR, erbB2, erbB3 and erbB4. These
receptors form ligand-activated oligomers which regulate intracellular processes via an …

US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …

Cetuximab (Erbitux®) is a human-mouse chimeric monoclonal antibody, which competitively
binds to the accessible extracellular domain of the epidermal growth factor receptor (EGFR) …

Squamous cell carcinoma of the head and neck (HNSCC) while curable in many cases with
surgery, radiation, and chemotherapy, remains a disease that is associated with significant …

Purpose: Gemcitabine-radiotherapy is a standard treatment for locally advanced pancreatic
cancer. Clinical data have shown that gemcitabine plus erlotinib is superior to gemcitabine …

Importance of the field: EGFR is an established therapeutic target in head and neck
squamous cell carcinoma (HNSCC). The EGFR-targeting monoclonal antibody cetuximab …

Chemoradiation is the standard therapy for the majority of inoperable, locally advanced
cancers. Although there is a need to improve chemoradiation efficacy, normal-tissue toxicity …

The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine
kinase inhibitors and monoclonal antibodies, with improvement in outcome in subsets of …

The epidermal growth factor receptor (EGFR) plays an important role in tumor progression
and treatment resistance for many types of malignancies including head and neck …