The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …

Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …

To further understand the molecular distinctions between kidney cancer subtypes, we
analyzed exome, transcriptome and copy number alteration data from 167 primary human …

The phenotypic transformation of well-differentiated epithelial carcinoma into a
mesenchymal-like state provides cancer cells with the ability to disseminate locally and to …

Serine proteases of the trypsin-like family have long been recognized to be critical effectors
of biological processes as diverse as digestion, blood coagulation, fibrinolysis, and …

The epithelial to mesenchymal transition (EMT) is a developmental process enabling
epithelial cells to gain a migratory mesenchymal phenotype. In cancer, this process …

MicroRNAs (miRNAs) are involved in the progression of many cancers through largely
unelucidated mechanisms. The results of our present study identified a gene cluster, miR …

Prostate cancer is the most common non-dermatologic malignancy in men in the Western
world. Recently, a frequent chromosomal aberration fusing androgen regulated TMPRSS2 …

Hepatocyte growth factor/scatter factor (HGF/SF) plays critical roles in cancer progression
through its specific receptor, MET. HGF/SF is usually synthesized and secreted as an …

Regulated proteolysis of cellular factors is pivotal to tissue development and homeostasis,
whereas uncontrolled proteolytic activity is linked to disease. Type II transmembrane serine …