Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

RESEARCH DESIGN AND METHODS The euglycemic insulin clamp technique (5) is
considered to be the gold standard for measuring insulin action in vivo. With this technique …

Protein phosphorylation dynamically integrates environmental and cellular information to
control biological processes. Identifying functional phosphorylation amongst the thousands …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell
dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Readers of this journal do not need to be re-minded of the explosive increase in obesity/type
2 diabetes syndromes and their attendant staggering public health costs that are currently …

Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis
of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

Increased plasma FFA reduce insulin-stimulated glucose uptake. The mechanisms
responsible for this inhibition, however, remain uncertain. It was the aim of this study to …